Ellagic acid is a naturally occurring phenolic constituent in certain fruits and nuts. With highest concentrations in red raspberries, ellagic acid has been proven an effective anti-mutagen, anti-carcinogen, and inhibitor of cancer.

Research at the Hollings Cancer Center at the Medical University of South Carolina (MUSC) indicate that ellagic acid slows the growth of abnormal colon cells in humans, prevents the development of cells infected with human papilloma virus (HPV), which is linked to cervical cancer, and promotes apoptotic growth (natural death) of prostate cancer cells. The apoptotic process triggered by this antioxidant also has beneficial effects on breast, lung, esophageal, and skin cancer (melanoma).

Dr. Daniel Nixon, MUSC, began studying the ellagic acid in red raspberries in 1993. His recently published results show:

• Cervical Cancer Cells — HPV (human papilloma virus) exposed to ellagic acid from red raspberries experienced apoptosis (normal cell death).
• Ellagic acid leads to G1 arrest of cancer cells, thus inhibiting and stopping mitosis (cancer cell division).
• Ellagic acid from red raspberries prevents destruction of the P53 gene by cancer cells. P53 is regarded as the safeguard of mutagenic activity in cervical cells.
• Tests reveal similar results for breast, pancreas, esophageal, skin, colon, and prostate cancer cells.
• Consuming one cup (150 grams) of red raspberries per day prevents the development of cancer cells.

Medical findings in Europe further show that ellagic acid reduces the incidence of birth defects, promotes wound healing, reduces and reverses chemically induced liver fibrosis, and is helpful in the fight against heart disease.

The availability to the body of ellagic acid from dietary sources has only been confirmed with red raspberries. Other foods such as strawberries, pomegranates, and walnuts contain ellagic acid yet the bioavailability has not been confirmed.

People with Stage 3 or 4 cancer using Ellagi-Red (4 to 8 tablets daily) report noticeable improvement in their condition in a short period of time (some as little as 10 days to 8 weeks)!

Ellagic Acid arrests cancerous cells –

Coral Calcium terminates the cause

Additional Studies Supporting the Use of Ellagic Acid as a Cancer Chemopreventative

David H. Barch, MD, Associate Professor of Medicine, Department of Medicine, Lakeside Veterans Affairs Medical Center, Chicago, IL.Ellagic acid induces NAD(P)H:quinone reductase through activation of the antioxidant responsive element of the rat NAD(P)H:quinone reductase gene. Barch, et al.

K.C. Thresiamma, J. George and R. Kuttan Amala Cancer Research Centre, Amala Nagar, Trichure, India.Protective Effect of Curcumin, Ellagic Acid and Bixin on Radiation InducedGenotoxicity.

Loarca-Pina, G., Kuzmicky P.A., de Mejia, E.G., Kado, N.Y., Departamento de Investigacion y Posgrado, Facultade de Quimica, Universidad Autonoma de Queretaro, Oro, Mexico. Inhibitory effects of ellagic acid on the direct-acting mutagenicity of aflatoxin B1 in the Salmonella microsuspension assay.

Suzuki M, Kumazawa N, Ohta S, Kamogawa A, Shinoda M, Faculty of Pharmaceutical Science, Hoshi University, Tokyo, Japan. Protective effects of antioxidants on experimental liver injuries.

Stoner GD, Adam-Rodwell G, Morse MA, Ohio State University, Department of Preventive Medicine, Arthur G. James Cancer Hospital and Research Institute, Columbus 43210. Lung tumors in strain A mice: application for studies in cancer chemoprevention.

Additional References on the Potential of Ellagic Acid on Cancer Prevention

Ahn D, Putt D, Kresty L, Stoner GD, Fromm D, Hollenberg PF, (1996). The effects of dietary ellagic acid on rat hepatic and esophageal mucosal cytochromes P450 and phase II enzymes. Carcinogenesis 17:821-828.

Corthout J, LA Pieters, M Claeys, DA Vanden Berghe, AJ Vlietinck, (1991). Antiviral ellagitannins from Spondiamombin. Phytochem. 30:1129-1130.

Daniel EM, AS Krupnick, Y-H Heur, JA Blinzler, RW Nims, GD Stoner, (1989). Extraction, stability, and quantitation of ellagic acid in various fruits and nuts. J. Food Comp. And Anal. 2:338-349.

Daniel EM, S. Ratnayake, T Kinstel, GD Stoner, (1991). The effects of pH and rat intestinal contents on the liberation of ellagic acid from purified and crude ellagitannins. J. of Natural Prod. 54:946-952.

Maas JL, GJ Galletta, GD Stoner, (1991a). Ellagic acid, an anticarcinogen in fruits, especially in strawberries: a review. HortSci. 26:10-14.

Maas JL, SY Want, GJ Galletta, (1991b). Evaluation of strawberry cultivars for ellagic acid content. HortSci. 26:66-68.

Maas JL, SY Want, GJ Galletta, Nishizawa K, I Nakata, A Kishida, WA Ayer, LM Browne, (1990). Some biologically active tannins of Nuphar variegatum. Phytochem. 29:2491-2494.

Peng S, A Scalbert, B Monties, (1991). Insoluble ellagitannins in Castanea sativa and Quercus petraea woods. Phytochem. 30:775-778.

Rao CV, Tokumo K, Rigotty J, Zang E, Kelloff G, Reddy BS, (1991). Chemoprevention of Colon Carcinogenesis by Dietary Administration of Piroxicam, Difluoromethylornithine, 16beta-Fluoro-5-androsten-17-one, and Ellagic Acid Individually and in Combination. Cancer Research 51:4528-4534.

Stoner GD, Morse MA, 1997). Isothiocyanates and plant polyphenols as inhibitors of lung and esophageal cancer. Cancer Letters 114:113-119.

Yoshida T, Z-X Jin, T Okuda, (1991). Hydrolysable tannin oligomers form Rosa davurica. Phytochem. 30:2747-2752.

Barch, DH, and Rundhaugen, LM (1994). Ellagic acid induces NAD(P)H:quinone. Barch, DH, Rundhaugen, LM, Thomas, PE, Pillay, NS, and Kardos, P (1994). Dietary reductase through activation of the antioxidant regulatory element of the rat NAD(P)H:quinone reductase gene. Carcinogenesis 15:2065-2068.

Barch, DH, Rundhaugen, LM, and Pillay, NS (1995). Ellagic acid induces transcription of the rat glutathione S-transferase Ya gene. Carcinogenesis 16:665-668.

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